منابع مشابه
Notice regarding HRSA grant requirement--participation in the 340B drug pricing program--HRSA. Notice.
Section 602 of Public Law 102-585, the "Veterans Health Care Act of 1992," enacted section 340B of the Public Health Service (PHS) Act, "Limitation on Prices of Drugs Purchased by Covered Entities." Section 340B provides that a manufacturer who sells covered outpatient drugs to eligible entities must sign a pharmaceutical pricing agreement with the Secretary of HHS in which the manufacturer agr...
متن کاملAttribution of posttransplantation toxicity to methotrexate regarding genotype of methylenetetrahydrofolate reductase gene (MTHFR) polymorphism needs further clarification.
We thank Drs Djulbegovic and Cohen for their comments on our recently published study.1 As they point out, we estimated the rate of fatal hemorrhage for patients with refractory idiopathic thrombocytopenic purpura (ITP) at 0.019 cases per patient-year at risk (where time at risk was defined as time with fewer than 30 3 109/L platelets), using a method previously described by Cohen et al.2 Unfor...
متن کاملSystematic review on the safety of methotrexate in rheumatoid arthritis regarding the reproductive system (fertility, pregnancy, and breastfeeding).
OBJECTIVE To analyze the safety of methotrexate (MTX) in rheumatoid arthritis (RA) regarding the reproductive system (fertility, pregnancy, and breastfeeding). METHODS Systematic review of studies retrieved by a sensitive search strategy in Medline (1961 - October 2007), Embase (1961 - October 2007), Cochrane Library (up to October 2007), and from the abstracts of the ACR (2005, 2006) and EUL...
متن کاملRole of methotrexate polyglutamates in methotrexate- and sequential methotrexate-5-fluorouracil-mediated cell kill.
The synthesis of methotrexate (MTX) polyglutamates has been investigated in a human leukemia cell line, CCRF-CEM. An increase in either the extracellular MTX concentration (0.1-10 microM) or exposure time (4-24 h) allowed a greater accumulation of polyglutamate derivatives. The species which predominated (di-, tri-, or tetraglutamate) was also time and concentration dependent. Derivatives up to...
متن کاملPricing Functionals and Pricing Measures
We demonstrate how pricing functionals give rise to pricing measures, using a time-independent framework. For infinite market state spaces, the Gel’fand spectral theory is used to obtain the pricing measure. Pricing functionals with additional market information are shown, within this model, to be given by conditional expectations.
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1990
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.1780330324